Article
Accelerated telomere attrition in children and teenagers with α1-antitrypsin deficiency.
The European respiratory journal - 1 Aug 2016
Escribano Amparo, Pastor Sara, Reula Ana, Castillo Silvia, Vicente Silvia, Sanz Francisco, Casas Francisco, Torres María, Fernández-Fabrellas Estrella, Codoñer-Franch Pilar, Dasí Francisco
Abstract excerpt
Numerous studies have shown that oxidative stress accelerates telomere shortening in several lung pathologies. Since oxidative stress is involved in the pathophysiology of α1-antitrypsin deficiency (AATD), we hypothesised that telomere shortening would be accelerated in AATD patients. This study aimed to assess telomere length in AATD patients and to study its association with α1-antitrypsin phenotypes.Telomere...
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