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Article

SAMHD1, the Aicardi-Goutières syndrome gene and retroviral restriction factor, is a phosphorolytic ribonuclease rather than a hydrolytic ribonuclease

4 Jul 2016

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 27387229
DOI: 10.1016/j.bbrc.2016.07.013

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SAMHD1, the Aicardi-Goutières syndrome gene and retroviral restriction factor, is a phosphorolytic ribonuclease rather than a hydrolytic ribonucleasePMID 27387229Read ↗

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune responseSemantic proximity Read ↗

Ribonuclease H2 in health and diseaseSemantic proximity Read ↗

Aicardi-Goutières Syndrome caused by SAMHD1 mutation: Pathogenesis and Beyond.Semantic proximity Read ↗

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SAMHD1 Functions and Human Diseases.Semantic proximity Read ↗

The Aicardi–Goutières syndrome. Molecular and clinical features of RNAse deficiency and microRNA overloadSemantic proximity Read ↗

A SAMHD1 mutation associated with Aicardi-Goutières syndrome uncouples the ability of SAMHD1 to restrict HIV-1 from its ability to downmodulate type I interferon in humans.Semantic proximity Read ↗

SAMHD1 controls nucleoside-based cancer therapeutics, deoxyguanosine toxicity, and inflammationSemantic proximity Read ↗

The ribonuclease activity of SAMHD1 is required for HIV-1 restriction.Semantic proximity Read ↗

Involvement of SAMHD1 in dNTP homeostasis and the maintenance of genomic integrity and oncotherapy (Review).Semantic proximity Read ↗

SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations.Semantic proximity Read ↗

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature.Semantic proximity Read ↗

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