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Article

Fragment-Based Discovery of Dual JC Virus and BK Virus Helicase Inhibitors

7 Jul 2016

Abstract excerpt

There are currently no treatments for life-threatening infections caused by human polyomaviruses JCV and BKV. We therefore report herein the first crystal structure of the hexameric helicase of JCV large T antigen (apo) and its use to drive the structure-based design of dual JCV and BKV ATP-competitive inhibitors. The crystal structures obtained by soaking our early inhibitors into the JCV helicase allowed us to...

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PMID: 27385654
DOI: 10.1021/acs.jmedchem.6b00486

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