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Dihydropyrimidinones and -thiones with improved activity against human polyomavirus family members

31 Aug 2016

Abstract excerpt

Human polyomaviruses are generally latent but can be reactivated in patients whose immune systems are suppressed. Unfortunately, current therapeutics for diseases associated with polyomaviruses are non-specific, have undefined mechanisms of action, or exacerbate the disease. We previously reported on a class of dihydropyrimidinones that specifically target a polyomavirus-encoded protein, T antigen, and/or inhibit...

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PMID: 27624078
DOI: 10.1016/j.bmcl.2016.08.080

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