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<i>In</i> <i>Vitro</i> and <i>In Vivo</i> Activities of the Novel Anticytomegalovirus Compound AIC246

5 Jan 2010

Abstract excerpt

Human cytomegalovirus (HCMV) remains a serious threat for immunocompromised individuals, including transplant recipients and newborns. To date, all drugs licensed for the treatment of HCMV infection and disease target the viral DNA polymerase. Although these drugs are effective, several drawbacks are associated with their use, including toxicity and emergence of drug resistance. Hence, new and improved antivirals...

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PMID: 20047911
DOI: 10.1128/aac.01596-09

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