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Article

Trilobatin as an HIV ‐1 entry inhibitor targeting the HIV ‐1 Gp41 envelope

26 May 2018

Abstract excerpt

HIV-1 transmembrane protein gp41 plays a crucial role by forming a stable six-helix bundle during HIV entry. Due to highly conserved sequence of gp41, the development of an effective and safe small-molecule compound targeting gp41 is a good choice. Currently, natural polyanionic ingredients with anti-HIV activities have aroused concern. Here, we first discovered that a glycosylated dihydrochalcone, trilobatin,...

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PMID: 29802645
DOI: 10.1002/1873-3468.13113

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