Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Network Analysis Implicates Alpha-Synuclein (Snca) in the Regulation of Ovariectomy-Induced Bone Loss.

Scientific reports - 5 Jul 2016

Calabrese Gina, Mesner Larry D, Foley Patricia L, Rosen Clifford J, Farber Charles R

Abstract excerpt

The postmenopausal period in women is associated with decreased circulating estrogen levels, which accelerate bone loss and increase the risk of fracture. Here, we gained novel insight into the molecular mechanisms mediating bone loss in ovariectomized (OVX) mice, a model of human menopause, using co-expression network analysis. Specifically, we generated a co-expression network consisting of 53 gene modules...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Estrogens
Share to Mice, Inbred C3H

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Osteoporosis, Postmenopausal

Share to Osteoporotic Fractures

Share to Ovariectomy

Share to Postmenopause

Share to X-Ray Microtomography

Source

Open in PubMed Open full text

Identifiers

PMID: 27378017
DOI: 10.1038/srep29475
PMCID: PMC4932518

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Network Analysis Implicates Alpha-Synuclein (Snca) in the Regulation of Ovariectomy-Induced Bone Loss.PMID 27378017Read ↗

Transcriptomic network analysis of brain and bone reveals shared molecular mechanisms underlying Alzheimer’s Disease and related dementias (ADRD) and OsteoporosisSemantic proximity Read ↗

Gene expression profile induced by ovariectomy in bone marrow of mice: a functional approach to identify new candidate genes associated to osteoporosis risk in women.Semantic proximity Read ↗

Age- and sex-specific deterioration on bone and osteocyte lacuno-canalicular network in a mouse model of premature agingSemantic proximity Read ↗

Sex-specific signatures of brain-wide induction of ΔFOSB and altered co-activation networks in a mouse model for exercise trainingSemantic proximity Read ↗

Bone loss in C57BL/6J-OlaHsd mice, a substrain of C57BL/6J carrying mutated alpha-synuclein and multimerin-1 genes.Semantic proximity Read ↗

The Circadian Gene Clock Regulates Bone Formation Via PDIA3Semantic proximity Read ↗

Integration of heterogeneous functional genomics data in gerontology research identifies genes and pathway underlying aging across speciesSemantic proximity Read ↗

Integration of heterogeneous functional genomics data in gerontology research to find genes and pathway underlying aging across species.Semantic proximity Read ↗

Bone turnover markers and transcriptomes changes induced by acute sleep deprivationSemantic proximity Read ↗

Long-term ovarian hormone deprivation alters functional connectivity, brain neurochemical profile and white matter integrity in the Tg2576 amyloid mouse model of Alzheimer's disease.Semantic proximity Read ↗

Changes in the MicroRNA Profile of the Mandible of Ovariectomized MiceSemantic proximity Read ↗

Altered extracellular matrix and mechanotransduction gene expression in rat bone tissue following long-term estrogen deficiencySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.