Article
The heterogeneous HLA genetic composition of the Brazilian population and its relevance to the optimization of hematopoietic stem cell donor recruitment.
Tissue antigens - 1 Aug 2014
Fabreti-Oliveira R A, Nascimento E, Fonseca C G, Santos M A
Abstract excerpt
The aim of this study was to investigate the human leukocyte antigen (HLA) molecular variation across the Brazilian population in order to determine possible regional differences, which would be highly relevant to optimizing donor recruitment strategies in hematopoietic stem cell transplantation (HSCT) and understanding the population genetic background of this heterogeneous country. HLA data of 551 HSCT donors...
Topics
- Adolescent
- Adult
- Alleles
- Brazil
- Donor Selection
- Gene Frequency
- Genetic Loci
- Genetic Variation
- Genetics, Population
- Geography
- HLA Antigens
- Haplotypes
- Hematopoietic Stem Cells
- Humans
- Linkage Disequilibrium
- Middle Aged
- Phylogeny
- Tissue Donors