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Whole-genome sequencing in French Canadians from Quebec.

Human genetics - 1 Nov 2016

Low-Kam Cécile, Rhainds David, Lo Ken Sin, Provost Sylvie, Mongrain Ian, Dubois Anick, Perreault Sylvie, Robinson John F, Hegele Robert A, Dubé Marie-Pierre, Tardif Jean-Claude, Lettre Guillaume

Abstract excerpt

Genome-wide association studies (GWAS) have had a tremendous success in the identification of common DNA sequence variants associated with complex human diseases and traits. However, because of their design, GWAS are largely inappropriate to characterize the role of rare and low-frequency DNA variants on human phenotypic variation. Rarer genetic variation is geographically more restricted, supporting the need for...

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PMID: 27376640
DOI: 10.1007/s00439-016-1702-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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