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Rare variants discovery by extensive whole-genome sequencing of the Han Chinese population in Taiwan: Applications to cardiovascular medicine.

Journal of advanced research - 1 May 2021

Juang Jyh-Ming Jimmy, Lu Tzu-Pin, Su Ming-Wei, Lin Chien-Wei, Yang Jenn-Hwai, Chu Hou-Wei, Chen Chien-Hsiun, Hsiao Yi-Wen, Lee Chien-Yueh, Chiang Li-Mei, Yu Qi-You, Hsiao Chuhsing Kate, Chen Ching-Yu Julius, Wu Pei-Ei, Pai Chien-Hua, Chuang Eric Y, Shen Chen-Yang

Abstract excerpt

Introduction: A population-specific genomic reference is important for research and clinical practice, yet it remains unavailable for Han Chinese (HC) in Taiwan. Objectives: We report the first whole genome sequencing (WGS) database of HC (1000 Taiwanese genome (1KTW-WGS)) and demonstrate several applications to cardiovascular medicine. Methods: Whole genomes of 997 HC were sequenced to at least 30X depth. A...

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Cardiovascular Diseases
Databases, Factual
Hyperlipidemias
Hypertension

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Vitamin K Epoxide Reductases

Whole Genome Sequencing

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PMID: 34026292
DOI: 10.1016/j.jare.2020.12.003
PMCID: PMC8132201

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