Article
Tumor Phenotype and Gene Expression During Early Mammary Tumor Development in Offspring Exposed to Alcohol In Utero.
Alcoholism, clinical and experimental research - 1 Aug 2016
Crismale-Gann Catina, Stires Hillary, Katz Tiffany A, Cohick Wendie S
Abstract excerpt
BACKGROUND: Alcohol exposure in utero increases susceptibility to carcinogen-induced mammary tumorigenesis in adult offspring and causes tumors with a more malignant phenotype. This study was conducted to identify changes early in tumor development that might lead to this outcome. METHODS: Pregnant Sprague-Dawley rats were fed a liquid diet containing 6.7% ethanol (alcohol), an isocaloric liquid diet without...
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