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Article

USP7 inhibitors, downregulating CCDC6, sensitize lung neuroendocrine cancer cells to PARP-inhibitor drugs.

Lung cancer (Amsterdam, Netherlands) - 1 May 2017

Malapelle Umberto, Morra Francesco, Ilardi Gennaro, Visconti Roberta, Merolla Francesco, Cerrato Aniello, Napolitano Virginia, Monaco Roberto, Guggino Gianluca, Monaco Guglielmo, Staibano Stefania, Troncone Giancarlo, Celetti Angela

Abstract excerpt

OBJECTIVES: CCDC6 gene product is a tumor-suppressor pro-apoptotic protein, substrate of ATM, involved in DNA damage response and repair. Altered levels of CCDC6 expression are dependent on post-translational modifications, being the de-ubiquitinating enzyme USP7 responsible of the fine tuning of the CCDC6 stability. Thus, our aim was to investigate CCDC6 and USP7 expression levels in Lung-Neuroendocrine Tumors...

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Source

Identifiers

PMID: 27372520
DOI: 10.1016/j.lungcan.2016.06.015

Genes

CCDC6
USP7
ALK
ATM
MET
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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