The origins and impact of primate segmental duplications.

doi:10.1016/j.tig.2009.08.002

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Article

The origins and impact of primate segmental duplications.

Trends in genetics : TIG - 1 Oct 2009

Marques-Bonet Tomas, Girirajan Santhosh, Eichler Evan E

Abstract excerpt

Duplicated sequences are substrates for the emergence of new genes and are an important source of genetic instability associated with rare and common diseases. Analyses of primate genomes have shown an increase in the proportion of interspersed segmental duplications (SDs) within the genomes of humans and great apes. This contrasts with other mammalian genomes that seem to have their recently duplicated sequences...

Topics

Animals
Evolution, Molecular
Gene Duplication
Genetic Variation
Genome
Humans
Interspersed Repetitive Sequences
Models, Genetic
Phylogeny
Primates

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Identifiers

PMID: 19796838
DOI: 10.1016/j.tig.2009.08.002
PMCID: PMC2847396

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