Article
Association of COL1A1 polymorphism with subchondral bone degeneration of the temporomandibular joint.
International journal of oral and maxillofacial surgery - 1 Dec 2016
Luo S, Long X, Deng M, Meng Q, Ke J, Guo H
Abstract excerpt
The G/T polymorphism of the COL1A1 gene exhibits a clinically significant influence on bone remodelling, leading to a predisposition to degenerative diseases. The enhancement of bone turnover and further loss of bone mass are thought to be the primary pathological changes in the early degenerative course of temporomandibular joint osteoarthritis (TMJ OA), with the appearance of low-density lesions. Thus, it was...
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