Article
The polymorphic hMSH5 C85T allele augments radiotherapy-induced spermatogenic impairment.
Andrology - 1 Sept 2016
Zhu Y, Gao G, Xia L, Li X, Wu X, Her C, Xu K
Abstract excerpt
The hMSH5 C85T polymorphism (encoding hMSH5 P29S) is associated with male infertility and radiation-induced apoptotic response. To date, however, the potential association of hMSH5 C85T polymorphism with DNA damage accumulation in spermatozoa of cancer patients treated with radiotherapy is largely unknown. We investigated hMSH5 C85T allele and genotype frequencies, routine semen analysis and sperm DNA...
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