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Article

Capsaicin triggers autophagic cell survival which drives epithelial mesenchymal transition and chemoresistance in bladder cancer cells in an Hedgehog-dependent manner.

Oncotarget - 2 Aug 2016

Amantini Consuelo, Morelli Maria Beatrice, Nabissi Massimo, Cardinali Claudio, Santoni Matteo, Gismondi Angela, Santoni Giorgio

Abstract excerpt

Bladder cancer (BC) is a common urologic tumor characterized by high risk of recurrence and mortality. Capsaicin (CPS), used as an intravesical drug for overactive bladder, was demonstrated to induce cell death in different cancer cells including BC cells.Here we found that treatment of high-grade BC cells with high dose of CPS triggers autophagy. Infact, the CPS treatment alters the redox homeostasis by inducing...

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Identifiers

PMID: 27367032
DOI: 10.18632/oncotarget.10326
PMCID: PMC5226576

Genes

ALCAM
PTCH2
TIMP1
VEGFA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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