Article
para-Phenylenediamine-induced autophagy in human uroepithelial cell line mediated mutant p53 and activation of ERK signaling pathway.
Toxicology in vitro : an international journal published in association with BIBRA - 1 Dec 2011
Huang Ya-Chun, Hung Wen-Chun, Chye Soi-Moi, Chen Wan-Tzu, Chai Chee-Yin
Abstract excerpt
para-Phenylenediamine (p-PD) is a major aromatic amine that is a widely used commercial oxidative-type hair dye. Some epidemiologic studies have suggested that the use of p-PD-based hair dyes might be related to increased risk of human malignant tumors including bladder cancer. However, the effects of p-PD on autophagy in human uroepithelial cells (SV-HUC-1) is still unclear. In this study, we demonstrate that...
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