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Gemcitabine and mitomycin induced autophagy regulates cancer stem cell pool in urothelial carcinoma cells

3 Dec 2015

Abstract excerpt

Urothelial carcinoma (UC) is characterized by therapeutic resistance and frequent tumor relapse. It has been suggested that UC are driven by a rare subset of cancer stem cells (CSCs). In order to understand UC recurrence post therapy, we investigated the behavior of urothelial CSCs after exposure to commonly used chemotherapeutic agents, gemcitabine (GC) and mitomycin (MM). Although, the role of autophagy in CSC...

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PMID: 26658162
DOI: 10.1016/j.bbamcr.2015.12.002

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