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Article

Influence of Polygenic Risk Scores on the Association Between Infections and Schizophrenia.

Biological psychiatry - 15 Oct 2016

Benros Michael E, Trabjerg Betina B, Meier Sandra, Mattheisen Manuel, Mortensen Preben B, Mors Ole, Børglum Anders D, Hougaard David M, Nørgaard-Pedersen Bent, Nordentoft Merete, Agerbo Esben

Abstract excerpt

BACKGROUND: Several studies have suggested an important role of infections in the etiology of schizophrenia; however, shared genetic liability toward infections and schizophrenia could influence the association. We therefore investigated the possible effect of polygenic risk scores (PRSs) for schizophrenia on the association between infections and the risk of schizophrenia. METHODS: We conducted a nested...

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PMID: 27364036
DOI: 10.1016/j.biopsych.2016.04.008

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