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Article

A next generation sequencing-based method to study the intra-host genetic diversity of norovirus in patients with acute and chronic infection.

BMC genomics - 1 Jul 2016

Hasing Maria E, Hazes Bart, Lee Bonita E, Preiksaitis Jutta K, Pang Xiaoli L

Abstract excerpt

BACKGROUND: Immunocompromised individuals with chronic norovirus (NoV) infection and elderly patients are hypothesized to be reservoirs where NoV might accumulate mutations and evolve into pandemic strains. Next generation sequencing (NGS) methods can monitor the intra-host diversity of NoV and its evolution but low abundance of viral RNA results in sub-optimal efficiency. In this study, we: 1) established a next...

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Identifiers

PMID: 27363999
DOI: 10.1186/s12864-016-2831-y
PMCID: PMC4929757

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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