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Article

Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia.

Genome biology - 29 Jun 2016

Haider Syed, McIntyre Alan, van Stiphout Ruud G P M, Winchester Laura M, Wigfield Simon, Harris Adrian L, Buffa Francesca M

Abstract excerpt

BACKGROUND: Altered metabolism is a hallmark of cancer. However, the role of genomic changes in metabolic genes driving the tumour metabolic shift remains to be elucidated. Here, we have investigated the genomic and transcriptomic changes underlying this shift across ten different cancer types. RESULTS: A systematic pan-cancer analysis of 6538 tumour/normal samples covering ten major cancer types identified a...

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Identifiers

PMID: 27358048
DOI: 10.1186/s13059-016-0999-8
PMCID: PMC4926297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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