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Article

Mitochondrial DNA Haplogroups and Susceptibility to Neuroblastoma.

Journal of the National Cancer Institute - 14 Dec 2020

Chang Xiao, Bakay Marina, Liu Yichuan, Glessner Joseph, Rathi Komal S, Hou Cuiping, Qu Huiqi, Vaksman Zalman, Nguyen Kenny, Sleiman Patrick M A, Diskin Sharon J, Maris John M, Hakonarson Hakon

Abstract excerpt

BACKGROUND: Neuroblastoma is a childhood malignancy that arises from the developing sympathetic nervous system. Although mitochondrial dysfunctions have been implicated in the pathophysiology of neuroblastoma, the role of mitochondrial DNA (mtDNA) has not been extensively investigated. METHODS: A total of 2404 Caucasian children diagnosed with neuroblastoma and 9310 ancestry-matched controls were recruited at the...

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Identifiers

PMID: 32096864
DOI: 10.1093/jnci/djaa024
PMCID: PMC7735767

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