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Article

Identification of basic residues involved in drug export function of human multidrug resistance-associated protein 2.

The Journal of biological chemistry - 15 Dec 2000

Ryu S, Kawabe T, Nada S, Yamaguchi A

Abstract excerpt

Multidrurg resistance-associated protein 2 (MRP2)/canalicular multispecific organic anion transporter (cMOAT) is involved in the ATP-dependent export of organic anions across the bile canalicular membrane. To identify functional amino acid residues that play essential roles in the substrate transport, each of 13 basic residues around transmembrane regions (TMs) 6-17 were replaced with alanine. Wild type and...

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Identifiers

PMID: 10978330
DOI: 10.1074/jbc.M005149200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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