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Article

Herpes simplex virus 1 induces egress channels through marginalized host chromatin

28 Jun 2016

Abstract excerpt

Lytic infection with herpes simplex virus type 1 (HSV-1) induces profound modification of the cell nucleus including formation of a viral replication compartment and chromatin marginalization into the nuclear periphery. We used three-dimensional soft X-ray tomography, combined with cryogenic fluorescence, confocal and electron microscopy, to analyse the transformation of peripheral chromatin during HSV-1...

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PMID: 27349677
DOI: 10.1038/srep28844

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