Article
Common sequence variants on 20q11.22 confer melanoma susceptibility.
Nature genetics - 1 Jul 2008
Brown Kevin M, Macgregor Stuart, Montgomery Grant W, Craig David W, Zhao Zhen Zhen, Iyadurai Kelly, Henders Anjali K, Homer Nils, Campbell Megan J, Stark Mitchell, Thomas Shane, Schmid Helen, Holland Elizabeth A, Gillanders Elizabeth M, Duffy David L, Maskiell Judith A, Jetann Jodie, Ferguson Megan, Stephan Dietrich A, Cust Anne E, Whiteman David, Green Adele, Olsson Håkan, Puig Susana, Ghiorzo Paola, Hansson Johan, Demenais Florence, Goldstein Alisa M, Gruis Nelleke A, Elder David E, Bishop Julia Newton, Kefford Richard F, Giles Graham G, Armstrong Bruce K, Aitken Joanne F, Hopper John L, Martin Nicholas G, Trent Jeffrey M, Mann Graham J, Hayward Nicholas K
Abstract excerpt
We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in...
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