Article
Treatment with aromatase inhibitors stimulates the expression of epidermal growth factor receptor-1 and neuregulin 1 in ER positive/HER-2/neu non-amplified primary breast cancers.
The Journal of steroid biochemistry and molecular biology - 1 Jan 2017
Flågeng Marianne Hauglid, Larionov Alexey, Geisler Jürgen, Knappskog Stian, Prestvik Wenche S, Bjørkøy Geir, Lilleng Peer Kåre, Dixon J Michael, Miller William R, Lønning Per Eystein, Mellgren Gunnar
Abstract excerpt
While estrogens have been shown to modulate EGFR/HER-1 and HER-2/neu expression in experimental systems, the effects of estrogen deprivation on expression levels of the HER-receptors and the neuregulin (NRG)1 ligand in breast cancers remain unknown. Here, we measured EGFR/HER-1-4 and NRG1 mRNA in ER positive tumors from 85 postmenopausal breast cancer patients before and after two weeks (n=64) and three months...
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