Article
Coordinated expression of oestrogen and androgen receptors in HER2-positive breast carcinomas: impact on proliferative activity.
Journal of clinical pathology - 1 Jan 2012
Lin Francini de Mattos Lima, Pincerato Katia Maciel, Bacchi Carlos Eduardo, Baracat Edmund Chada, Carvalho Filomena Marino
Abstract excerpt
AIMS: Human epidermal growth factor receptor 2 (HER2)-positive breast cancers are aggressive neoplasms associated with a variable response to systemic therapies. Therefore, the identification of biomarkers to better characterise this heterogeneity would improve treatment efficacy. The aim of this study was to evaluate the influence of androgen receptor (AR) and oestrogen receptor (ER) on clinicopathological...
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