Article
[Research Progress on Spliceosome Mutations in Hematopoietic Malignancy].
Zhongguo shi yan xue ye xue za zhi - 1 Jun 2016
Sun Chao, Wang Jing, Zhou Xin
Abstract excerpt
As novel somatic mutations, spliceosome mutations have been identified in recent years with the advent of whole exone/genome sequencing technology in hematopoietic malignancy. These new findings provide another view to understand these diseases other than DNA methylation, chromatin modification, transcription regulation, DNA repair and signal transduction. In this review, the structure as well as function of...
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