Article
BRAF and MEK gene rearrangements in melanoma: implications for targeted therapy.
Molecular diagnosis & therapy - 1 Jun 2014
Madureira Pedro, de Mello Ramon Andrade
Abstract excerpt
The incidence of melanoma has been continuously increasing in the last decades, and faster than any other cancers. Melanoma is the leading cause of death from skin disease. It is estimated that 76,690 Americans will be diagnosed with melanoma in 2013 and 9,480 will die from the disease. Molecular mechanisms underlying melanoma pathogenesis have been extensively studied and novel therapeutic weapons developed....
Topics
- Antineoplastic Agents
- Antineoplastic Combined Chemotherapy Protocols
- Gene Rearrangement
- Humans
- MAP Kinase Kinase Kinases
- MAP Kinase Signaling System
- Melanoma
- Molecular Targeted Therapy
- Mutation
- Neoplasm Metastasis
- Precision Medicine
- Proto-Oncogene Proteins B-raf