Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Candida albicans homologue of PIG-P, CaGpi19p: gene dosage and role in growth and filamentation.

Microbiology (Reading, England) - 1 Oct 2010

Victoria Guiliana Soraya, Kumar Pravin, Komath Sneha Sudha

Abstract excerpt

Glycosylphosphatidyl inositol (GPI)-anchored proteins in Candida albicans are responsible for a vast range of functions, and deletions in certain GPI-anchored proteins severely reduce adhesion and virulence of this organism. In addition, completely modified GPIs are necessary for virulence. GPI anchor biosynthesis is essential for viability and starts with the transfer of N-acetylglucosamine to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Candida albicans
Share to Cell Wall
Share to Fungal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Dosage

Share to Genetic Complementation Test

Share to Glucosyltransferases

Share to Hyphae

Share to Saccharomyces cerevisiae Proteins

Source

Identifiers

PMID: 20576690
DOI: 10.1099/mic.0.039628-0

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Candida albicans homologue of PIG-P, CaGpi19p: gene dosage and role in growth and filamentation.PMID 20576690Read ↗

The catalytic subunit of the first mannosyltransferase in the GPI biosynthetic pathway affects growth, cell wall integrity and hyphal morphogenesis in Candida albicans.Semantic proximity Read ↗

First step of glycosylphosphatidylinositol (GPI) biosynthesis cross-talks with ergosterol biosynthesis and Ras signaling in Candida albicans.Semantic proximity Read ↗

The Aspergillus nidulans pigP gene encodes a subunit of GPI-N-acetylglucosaminyltransferase which influences filamentation and protein secretion.Semantic proximity Read ↗

Gpi19, the Saccharomyces cerevisiae homologue of mammalian PIG-P, is a subunit of the initial enzyme for glycosylphosphatidylinositol anchor biosynthesis.Semantic proximity Read ↗

Characterising N-acetylglucosaminylphosphatidylinositol de-N-acetylase (CaGpi12), the enzyme that catalyses the second step of GPI biosynthesis in Candida albicans.Semantic proximity Read ↗

Temperature-sensitive yeast GPI anchoring mutants gpi2 and gpi3 are defective in the synthesis of N-acetylglucosaminyl phosphatidylinositol. Cloning of the GPI2 gene.Semantic proximity Read ↗

Plasma membrane phosphatidylinositol-4-phosphate is not necessary for <i>Candida albicans</i> viability, yet is key for cell wall integrity and systemic infectionSemantic proximity Read ↗

A conditionally lethal yeast mutant blocked at the first step in glycosyl phosphatidylinositol anchor synthesis.Semantic proximity Read ↗

Aneuploidy and gene dosage regulate filamentation and host colonization by Candida albicansSemantic proximity Read ↗

The GPI-modified proteins Pga59 and Pga62 of Candida albicans are required for cell wall integritySemantic proximity Read ↗

Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositolSemantic proximity Read ↗

A novel intellectual disability syndrome caused by GPI anchor deficiency due to homozygous mutations in PIGT.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.