Article
Kras mutations increase telomerase activity and targeting telomerase is a promising therapeutic strategy for Kras-mutant NSCLC.
Oncotarget - 3 Jan 2017
Liu Weiran, Yin Yuesong, Wang Jun, Shi Bowen, Zhang Lianmin, Qian Dong, Li Chenguang, Zhang Hua, Wang Shengguang, Zhu Jinfang, Gao Liuwei, Zhang Qiang, Jia Bin, Hao Ligang, Wang Changli, Zhang Bin
Abstract excerpt
As shortened telomeres inhibit tumor formation and prolong life span in a KrasG12D mouse lung cancer model, we investigated the implications of telomerase in Kras-mutant NSCLC. We found that Kras mutations increased TERT (telomerase reverse transcriptase) mRNA expression and telomerase activity and telomere length in both immortalized bronchial epithelial cells (BEAS-2B) and lung adenocarcinoma cells (Calu-3)....
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