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The Z-cad dual fluorescent sensor detects dynamic changes between the epithelial and mesenchymal cellular states

17 Jun 2016

Abstract excerpt

BACKGROUND: The epithelial to mesenchymal transition (EMT) has been implicated in metastasis and therapy resistance of carcinomas and can endow cancer cells with cancer stem cell (CSC) properties. The ability to detect cancer cells that are undergoing or have completed EMT has typically relied on the expression of cell surface antigens that correlate with an EMT/CSC phenotype. Alternatively these cells may be...

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PMID: 27317311
DOI: 10.1186/s12915-016-0269-y

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