Article
Recurrent multilocular mandibular giant cell granuloma in neurofibromatosis type 1: Evidence for second hit mutation of NF1 gene in the jaw lesion and treatment with curettage and bone substitute materials.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery - 1 Aug 2016
Friedrich Reinhard E, Grob Tobias J, Hollants Silke, Zustin Jozef, Spaepen Marijke, Mautner Victor F, Luebke Andreas M, Hagel Christian, Legius Eric, Brems Hilde
Abstract excerpt
Giant cell granuloma (GCG) of the jaw is a rare, well-known feature of neurofibromatosis type 1 (NF1), an inborn multisystem disorder. Recently, the development of GCG in NF1 was attributed to second hit mutations in the NF1 gene. The treatment of GCG is pragmatic with a preference for local curettage of lytic osseous areas. This report describes the surgical therapy of an NF1-affected female with multilocular...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.