PI3K Pathway Inhibition Achieves Potent Antitumor Activity in Melanoma Brain Metastases In Vitro and In Vivo.

doi:10.1158/1078-0432.CCR-16-0064

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Article

PI3K Pathway Inhibition Achieves Potent Antitumor Activity in Melanoma Brain Metastases In Vitro and In Vivo.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2016

Niessner Heike, Schmitz Jennifer, Tabatabai Ghazaleh, Schmid Andreas M, Calaminus Carsten, Sinnberg Tobias, Weide Benjamin, Eigentler Thomas K, Garbe Claus, Schittek Birgit, Quintanilla-Fend Leticia, Bender Benjamin, Mai Marion, Praetorius Christian, Beissert Stefan, Schackert Gabriele, Muders Michael H, Meinhardt Matthias, Baretton Gustavo B, Dummer Reinhard, Flaherty Keith, Pichler Bernd J, Kulms Dagmar, Westphal Dana, Meier Friedegund

Abstract excerpt

PURPOSE: Great advances have recently been made in treating patients with metastatic melanoma. However, existing therapies are less effective on cerebral than extracerebral metastases. This highlights the potential role of the brain environment on tumor progression and drug resistance and underlines the need for "brain-specific" therapies. We previously showed that the PI3K-AKT survival pathway is hyperactivated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27307593
DOI: 10.1158/1078-0432.CCR-16-0064

Genes

BRAF
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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