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Article

HDAC6 regulates primordial follicle activation through mTOR signaling pathway

29 May 2021

Abstract excerpt

Primordial follicle pool established perinatally is a non-renewable resource which determines the female fecundity in mammals. While the majority of primordial follicles in the primordial follicle pool maintain dormant state, only a few of them are activated into growing follicles in adults in each cycle. Excessive activation of the primordial follicles accelerates follicle pool consumption and leads to premature...

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PMID: 34052832
DOI: 10.1038/s41419-021-03842-1

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