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Article

Oocyte-dependent activation of MTOR in cumulus cells controls the development and survival of cumulus-oocyte complexes.

Journal of cell science - 15 Aug 2016

Guo Jing, Shi Lanying, Gong Xuhong, Jiang Mengjie, Yin Yaoxue, Zhang Xiaoyun, Yin Hong, Li Hui, Emori Chihiro, Sugiura Koji, Eppig John J, Su You-Qiang

Abstract excerpt

Communication between oocytes and their companion somatic cells promotes the healthy development of ovarian follicles, which is crucial for producing oocytes that can be fertilized and are competent to support embryogenesis. However, how oocyte-derived signaling regulates these essential processes remains largely undefined. Here, we demonstrate that oocyte-derived paracrine factors, particularly GDF9 and...

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Source

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Identifiers

PMID: 27358481
DOI: 10.1242/jcs.182642
PMCID: PMC5004896

Genes

MTOR
GDF9
BMP15
RPS6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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