Article
Somatic mutation in the HLA-B gene of a patient with acute myelogenous leukaemia.
HLA - 1 Jul 2016
Planelles D, Balas A, Gil C, Muñoz C, Rodríguez-Cebriá M, Vicario J L
Abstract excerpt
In this report we describe a case of somatic mutation in the HLA-B gene in the tumour cells of a patient with acute myelogenous leukaemia (AML). Routine human leukocyte antigen (HLA) typing of patient by serology and molecular methodologies rendered discrepant results regarding the expression of a B*15:01 antigen. Sequencing-based typing of a patient's sample including a very high percentage of blast cells...
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