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Article

Laquinimod decreases Bax expression and reduces caspase-6 activation in neurons.

Experimental neurology - 1 Sept 2016

Ehrnhoefer Dagmar E, Caron Nicholas S, Deng Yu, Qiu Xiaofan, Tsang Michelle, Hayden Michael R

Abstract excerpt

Laquinimod is an immunomodulatory compound that has shown neuroprotective benefits in clinical trials for multiple sclerosis. Laquinimod ameliorates both white and gray matter damage in human patients, and prevents axonal degeneration in animal models of multiple sclerosis. Axonal damage and white matter loss are a common feature shared between different neurodegenerative diseases. Caspase-6 activation plays an...

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PMID: 27296315
DOI: 10.1016/j.expneurol.2016.06.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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