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Article

Developmental exposure to lead (Pb) alters the expression of the human tau gene and its products in a transgenic animal model.

Neurotoxicology - 1 Jul 2016

Dash M, Eid A, Subaiea G, Chang J, Deeb R, Masoud A, Renehan W E, Adem A, Zawia N H

Abstract excerpt

Tauopathies are a class of neurodegenerative diseases associated with the pathological aggregation of the tau protein in the human brain. The best known of these illnesses is Alzheimer's disease (AD); a disease where the microtubule associated protein tau (MAPT) becomes hyperphosphorylated (lowering its binding affinity to microtubules) and aggregates within neurons in the form of neurofibrillary tangles (NFTs)....

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Identifiers

PMID: 27293183
DOI: 10.1016/j.neuro.2016.06.001
PMCID: PMC5738909

Genes

CDK5
MAPT

Provenance

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