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Article

MAP17 Is a Necessary Activator of Renal Na+/Glucose Cotransporter SGLT2.

Journal of the American Society of Nephrology : JASN - 1 Jan 2017

Coady Michael J, El Tarazi Abdulah, Santer René, Bissonnette Pierre, Sasseville Louis J, Calado Joaquim, Lussier Yoann, Dumayne Christopher, Bichet Daniel G, Lapointe Jean-Yves

Abstract excerpt

The renal proximal tubule reabsorbs 90% of the filtered glucose load through the Na+-coupled glucose transporter SGLT2, and specific inhibitors of SGLT2 are now available to patients with diabetes to increase urinary glucose excretion. Using expression cloning, we identified an accessory protein, 17 kDa membrane-associated protein (MAP17), that increased SGLT2 activity in RNA-injected Xenopus oocytes by two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27288013
DOI: 10.1681/ASN.2015111282
PMCID: PMC5198278

Genes

PDZK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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