Article
Treatment With Human Wharton's Jelly-Derived Mesenchymal Stem Cells Attenuates Sepsis-Induced Kidney Injury, Liver Injury, and Endothelial Dysfunction.
Stem cells translational medicine - 1 Aug 2016
Cóndor José M, Rodrigues Camila E, Sousa Moreira Roberto de, Canale Daniele, Volpini Rildo A, Shimizu Maria H M, Camara Niels O S, Noronha Irene de L, Andrade Lúcia
Abstract excerpt
UNLABELLED: : The pathophysiology of sepsis involves complex cytokine and inflammatory mediator networks. Downregulation of endothelial nitric oxide synthase contributes to sepsis-induced endothelial dysfunction. Human Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) are known to reduce expression of proinflammatory cytokines and markers of apoptosis. We hypothesized that treatment with WJ-MSCs would...
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