Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of detergent binding on cytochrome P450 2B4 structure as analyzed by X-ray crystallography and deuterium-exchange mass spectrometry.

Biophysical chemistry - 1 Sept 2016

Shah Manish B, Jang Hyun-Hee, Wilderman P Ross, Lee David, Li Sheng, Zhang Qinghai, Stout C David, Halpert James R

Abstract excerpt

Multiple crystal structures of CYP2B4 have demonstrated the binding of the detergent 5-cyclohexyl-1-pentyl-β-D-maltoside (CYMAL-5) in a peripheral pocket located adjacent to the active site. To explore the consequences of detergent binding, X-ray crystal structures of the peripheral pocket mutant CYP2B4 F202W were solved in the presence of hexaethylene glycol monooctyl ether (C8E6) and CYMAL-5. The structure in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aryl Hydrocarbon Hydroxylases
Share to Catalytic Domain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crystallography, X-Ray

Share to Cytochrome P450 Family 2

Share to Detergents

Share to Deuterium Exchange Measurement

Share to Glucosides

Share to Mass Spectrometry

Source

Open in PubMed Open full text

Identifiers

PMID: 27280734
DOI: 10.1016/j.bpc.2016.05.007
PMCID: PMC4983516

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of detergent binding on cytochrome P450 2B4 structure as analyzed by X-ray crystallography and deuterium-exchange mass spectrometry.PMID 27280734Read ↗

A dual sensor regulates P-glycoprotein’s structural plasticitySemantic proximity Read ↗

Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations.Semantic proximity Read ↗

Ligandability at the membrane interface of GPx4 revealed through a reverse micelle fragment screening platformSemantic proximity Read ↗

Using Hydrogen-Deuterium Exchange Mass Spectrometry to Examine Protein-Membrane Interactions.Semantic proximity Read ↗

Probing the dynamic regulation of peripheral membrane proteins using hydrogen deuterium exchange-MS (HDX-MS).Semantic proximity Read ↗

Structure-function analysis of cytochromes P450 2B.Semantic proximity Read ↗

Impact of peripheral mutations on the access channels of human cytochrome P450 1A2Semantic proximity Read ↗

Molecular Dynamics Simulations Reveal Structural Differences among Allelic Variants of Membrane-Anchored Cytochrome P450 2D6.Semantic proximity Read ↗

Structural and functional effects of cytochrome b5 interactions with human cytochrome P450 enzymes.Semantic proximity Read ↗

A model of the membrane-bound cytochrome b5-cytochrome P450 complex from NMR and mutagenesis data.Semantic proximity Read ↗

Stabilization and spectroscopic characterization of the dioxygen complex of wild-type cytochrome P4502B4 (CYP2B4) and its distal side E301Q, T302A and proximal side F429H mutants at subzero temperatures.Semantic proximity Read ↗

Structural background of cyclodextrin-protein interactions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.