Article
A single mutation in the PBC loop of VP2 is involved in the in vitro replication of infectious bursal disease virus.
Science China. Life sciences - 1 Jul 2016
Qi Xiaole, Gao Xiang, Lu Zhen, Zhang Lizhou, Wang Yongqiang, Gao Li, Gao Yulong, Li Kai, Gao Honglei, Liu Changjun, Cui Hongyu, Zhang Yanping, Wang Xiaomei
Abstract excerpt
To test whether amino acid mutations in the PBC and PHI loops of VP2 are involved in the replication and virulence of infectious bursal disease virus (IBDV), a pair of viruses, namely the moderately virulent IBDV (rGx-F9VP2) and the attenuated strain (rGt), were used. Residue mutations A222P (PBC) and S330R (PHI), selected by sequence comparison, were introduced individually into rGx-F9VP2 by using a reverse...
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