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Article

Mutations of residues 249 and 256 in VP2 are involved in the replication and virulence of infectious Bursal disease virus.

PloS one - 1 Jan 2013

Qi Xiaole, Zhang Lizhou, Chen Yuming, Gao Li, Wu Guan, Qin Liting, Wang Yongqiang, Ren Xiangang, Gao Yulong, Gao Honglei, Wang Xiaomei

Abstract excerpt

Infectious bursal disease virus (IBDV) is a pathogen of worldwide significance to the poultry industry. Although the PDE and PFG domains of the capsid protein VP2 contribute significantly to virulence and fitness, the detailed molecular basis for the pathogenicity of IBDV is still not fully understood. Because residues 253 and 284 of VP2 are not the sole determinants of virulence, we hypothesized that other...

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Identifiers

PMID: 23923037
DOI: 10.1371/journal.pone.0070982
PMCID: PMC3724781

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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