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Changes in VP2 Gene During the Attenuation of Very Virulent Infectious Bursal Disease Virus Strain Gx Isolated in China

1 Jan 2004

Abstract excerpt

Very virulent (vv) infectious bursal disease virus (IBDV) Gx strain with high pathogenicity was attenuated through replication in specific-pathogen-free (SPF) chicken embryos and in chicken embryo fibroblast (CEF) cell cultures. The changes in VP2 nucleotide and the deduced amino acid sequences were obtained during attenuation of vvIBDV in CEF culture. Sequence analysis of selected passages from numbers 0 to 20...

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PMID: 15077800
DOI: 10.1637/7061

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