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Article

Mutational Analysis of Prostate-Specific Antigen Defines the Intrinsic Proteolytic Activity of the proPSA Zymogen.

The Prostate - 1 Sept 2016

Sangster-Guity Niquiche, Tu-Sekine Becky, Raben Daniel M, Denmeade Samuel R, Williams Simon A

Abstract excerpt

BACKGROUND: Prostate-specific antigen (PSA) is an important prostate cancer biomarker. It is also a protease expressed at high concentrations by the normal and malignant prostate. PSA is secreted as a zymogen (proPSA) with an inhibitory prodomain that must be removed for full activity. ProPSA variants, assumed to be inactive, are found in the blood of prostate cancer patients, and are indicative of poor clinical...

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PMID: 27273171
DOI: 10.1002/pros.23216

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