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Article

Structural Model of Human PSA: A Target for Prostate Cancer Therapy

10 Aug 2007

Abstract excerpt

Based on unique biology of prostate cancer, prostate-specific antigen could be a useful target for prostate cancer therapies. Such targeting requires the identification of highly selective inhibitor-binding sites. Three-dimensional structure was calculated by homology modeling. The overall structure of human prostate-specific antigen is composed of two beta-barrel domain, kallikrein loop and active-site triad...

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PMID: 17718721
DOI: 10.1111/j.1747-0285.2007.00553.x

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