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Article

TNF-insulin crosstalk at the transcription factor GATA6 is revealed by a model that links signaling and transcriptomic data tensors.

Science signaling - 7 Jun 2016

Chitforoushzadeh Zeinab, Ye Zi, Sheng Ziran, LaRue Silvia, Fry Rebecca C, Lauffenburger Douglas A, Janes Kevin A

Abstract excerpt

Signal transduction networks coordinate transcriptional programs activated by diverse extracellular stimuli, such as growth factors and cytokines. Cells receive multiple stimuli simultaneously, and mapping how activation of the integrated signaling network affects gene expression is a challenge. We stimulated colon adenocarcinoma cells with various combinations of the cytokine tumor necrosis factor (TNF) and the...

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Identifiers

PMID: 27273097
DOI: 10.1126/scisignal.aad3373
PMCID: PMC4914393

Genes

GATA6
TNF
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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