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Article

Dihydropyrimidine dehydrogenase (DPD) expression is negatively regulated by certain microRNAs in human lung tissues.

Lung cancer (Amsterdam, Netherlands) - 1 Jul 2012

Hirota Takeshi, Date Yuko, Nishibatake Yu, Takane Hiroshi, Fukuoka Yasushi, Taniguchi Yuuji, Burioka Naoto, Shimizu Eiji, Nakamura Hiroshige, Otsubo Kenji, Ieiri Ichiro

Abstract excerpt

Dihydropyrimidine dehydrogenase (DPD) is important to the antitumor effect of 5-fluorouracil (5-FU). DPD gene (DPYD) expression in tumors is correlated with sensitivity to 5-FU. Because the 5-FU accumulated in cancer cells is also rapidly converted into inactivated metabolites through catabolic pathways mediated by DPD, high DPD activity in cancer cells is an important determinant of the response to 5-FU. DPD...

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Identifiers

PMID: 22306127
DOI: 10.1016/j.lungcan.2011.12.018

Genes

DPYD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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