Article
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.
Nature genetics - 1 Jun 2013
Fingerlin Tasha E, Murphy Elissa, Zhang Weiming, Peljto Anna L, Brown Kevin K, Steele Mark P, Loyd James E, Cosgrove Gregory P, Lynch David, Groshong Steve, Collard Harold R, Wolters Paul J, Bradford Williamson Z, Kossen Karl, Seiwert Scott D, du Bois Roland M, Garcia Christine Kim, Devine Megan S, Gudmundsson Gunnar, Isaksson Helgi J, Kaminski Naftali, Zhang Yingze, Gibson Kevin F, Lancaster Lisa H, Cogan Joy D, Mason Wendi R, Maher Toby M, Molyneaux Philip L, Wells Athol U, Moffatt Miriam F, Selman Moises, Pardo Annie, Kim Dong Soon, Crapo James D, Make Barry J, Regan Elizabeth A, Walek Dinesha S, Daniel Jerry J, Kamatani Yoichiro, Zelenika Diana, Smith Keith, McKean David, Pedersen Brent S, Talbert Janet, Kidd Raven N, Markin Cheryl R, Beckman Kenneth B, Lathrop Mark, Schwarz Marvin I, Schwartz David A
Abstract excerpt
We performed a genome-wide association study of non-Hispanic, white individuals with fibrotic idiopathic interstitial pneumonias (IIPs; n = 1,616) and controls (n = 4,683), with follow-up replication analyses in 876 cases and 1,890 controls. We confirmed association with TERT at 5p15, MUC5B at 11p15 and the 3q26 region near TERC, and we identified seven newly associated loci (Pmeta = 2.4 × 10(-8) to 1.1 ×...
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